Colchicine and new antiinflammatory drugs for the treatment of acute gout
نویسندگان
چکیده
منابع مشابه
Colchicine for acute gout.
Evidence-Based Answer Low-quality evidence shows that low-dose colchicine (up to 1.8 mg over one hour) is an effective therapy for acute gout. However, it has not been compared with nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids in clinical trials. Concerns include high cost, drug-drug interactions, and potential toxicity. (Strength of Recommendation: B, based on inconsistent ...
متن کاملFormulation of colchicine ointment for the treatment of acute gout.
INTRODUCTION In spite of being the fastest acting drug available for the control of an acute gout attack, colchicine is generally considered a last alternative in gout therapy. This is mainly due to the severe adverse effects associated with its administration through the enteral and parenteral routes, as well as its high risk/benefit ratio. The preparation of dosage forms of colchicine that ca...
متن کاملColchicine overdose with coingestion of nonsteroidal antiinflammatory drugs.
Colchicine has a low therapeutic index. Its toxic effects generally occur at doses ≥ 0.5 mg/kg. We present the case of a 39-year-old female with toxicity following ingestion of 0.28 mg/kg. The patient presented to the emergency department (ED) with severe nausea, vomiting, and abdominal pain following an intentional multidrug ingestion that included colchicine, indomethacin, and zopiclone. Desp...
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چکیده ندارد.
15 صفحه اولNonsteroidal antiinflammatory drugs for adjunctive tuberculosis treatment.
Tuberculosis continues to cause 1.4 million deaths annually despite effective treatment being available since the 1970s. The standard 4-drug tuberculosis treatment regimen involving isoniazid, rifampicin, pyrazinamide, and ethambutol achieves 90%cure rates in programmatic settings [1]. Mycobacterium tuberculosis bacilli are difficult to eradicate since they exist in a spectrum of replication st...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 1975
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.1780180730